Huntington disease like 2 (HDL-2) with parkinsonism and abnormal DAT-SPECT – A novel observation
نویسندگان
چکیده
منابع مشابه
A comparison of huntington disease and huntington disease-like 2 neuropathology.
Huntington disease-like 2 (HDL2) is an autosomal dominant disorder characterized by adult-onset, progressive motor abnormalities, psychiatric disturbances, and dementia ending in premature death. Clinically, it most closely resembles Huntington disease (HD), although a subset of affected individuals have parkinsonian features. Here, we systematically compare 5 HDL2 and 5 HD brains with the hypo...
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1. Kanazawa M, Shimohata T, Sato M, Onodera O, Tanaka K, Nishizawa M. Botulinum toxin A injections improve apraxia of eyelid opening without overt blepharospasm associated with neurodegenerative diseases. Mov Disord 2007;22:597-598. 2. Lepore FE, Duvoisin RC. “Apraxia” of eyelid opening: an involuntary levator inhibition. Neurology 1985;35:423-427. 3. Jankovic J. Pretarsal injection of botulinu...
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Huntington disease-like 2 (HDL2) and Huntington disease (HD) are adult-onset neurodegenerative diseases characterized by movement disorders, psychiatric disturbances and cognitive decline. Brain tissue from HD and HDL2 patients shows degeneration of the striatum and ubiquitinated inclusions immunoreactive for polyglutamine (polyQ) antibodies. Despite these similarities, the diseases result from...
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ژورنال
عنوان ژورنال: Parkinsonism & Related Disorders
سال: 2020
ISSN: 1353-8020
DOI: 10.1016/j.parkreldis.2020.01.008